ASIO4ALL - Universal ASIO Driver This might protects you from the "driver grabbers" but it's still worth shutting down unnecessary stuff for audio work. A dedicated USB interface would be ideal but, as a stop gap you might try installing ASIO4ALL and using that with your existing sound card.
In the longer run you'll be better off with an interface that can run on ASIO drivers since these bypass the Windows system and its audio drivers. I think it's a pretty fair bet that the problem is simply that installing Windows 10 has changed something else to a default setting where it grabs the MME audio at certain intervals. That's why I say to shut down anything else that may be grabbing your sound card.anything from Windows sounds to the Media Player to Facebook automatically opening a video to play can be the culprit. You have to physically turn off whatever is using the computer's sound system and then tell Audition it's there and to use it. Audition (for various reasons) is set up not to steal the drivers away from other programmes. If you're using the basic Windows MME drivers, other programmes-like Windows Media Play since you mentioned it-will grab the audio card and not let go. It DOES matter if you have an "audio system" because Audition exhibits exactly the symptoms you describe if it's not connected to your sound card/audio interface. That's exactly what we were responding to. (It is not the same as playing and not producing sound.) It will not respond when the PLAY icon is pressed, it becomes non-responsive to any command after that. Windows Media Player and all the other audio programs perform well. Nero's Wave Editor software performs well. It worked fine yesterday on Windows 8.1 and will not today on Windows 10. It doesn't matter at this point if I have an audio system or not, Audition will not respond when the PLAY button is pressed. I was pointing out that the problem was the program is unresponsive when the play button is pressed. All the responses I've read thus far appear that the problem was an audio driver or a speaker wasn't plugged it and they weren't hearing audio sound.